abstract：:The mitochondrial trifunctional protein (MTP) is a heterotrimeric protein that consists of four alpha-subunits and four beta-subunits and catalyzes three of the four chain-shortening reactions in the mitochondrial beta-oxidation of long-chain fatty acids. Families with recessively inherited MTP defects display a spect...

journal_title：Advanced drug delivery reviews

authors： Rector RS,Payne RM,Ibdah JA

更新日期：2008-10-01 00:00:00

abstract：:The recent developments of nuclear medicine in oncology have involved numerous investigations of novel specific tumor-targeting radiopharmaceuticals as a major area of interest for both cancer imaging and therapy. The current progress in pharmaceutical nanotechnology field has been exploited in the design of tumor-tar...

journal_title：Advanced drug delivery reviews

authors： Hamoudeh M,Kamleh MA,Diab R,Fessi H

更新日期：2008-09-01 00:00:00

abstract：:Microbubbles are used as ultrasonic contrast agents that enhance the ultrasound signals of the vascular bed. The recent development of site-targeted microbubbles opened up the possibility for molecular imaging as well as localised drug and gene delivery. Initially the microbubbles' physical properties and their respon...

journal_title：Advanced drug delivery reviews

authors： Sboros V

更新日期：2008-06-30 00:00:00

abstract：:The supramolecular structures formed between cyclodextrins (CDs) and polymers have inspired interesting developments of novel supramolecular biomaterials. This review will update the recent progress in studies on supramolecular structures based on CDs and block copolymers, followed by the design and synthesis of CD-ba...

journal_title：Advanced drug delivery reviews

authors： Li J,Loh XJ

更新日期：2008-06-10 00:00:00

abstract：:High-throughput, combinatorial methods have revolutionized small molecule synthesis and drug discovery. By combining automation, miniaturization, and parallel synthesis techniques, large collections of new compounds have been synthesized and screened. It is becoming increasingly clear that these same approaches can al...

journal_title：Advanced drug delivery reviews

authors： Goldberg M,Mahon K,Anderson D

更新日期：2008-06-10 00:00:00

abstract：:Toxicity of nanocarrier systems involves physiological, physicochemical, and molecular considerations. Nanoparticle exposures through the skin, the respiratory tract, the gastrointestinal tract and the lymphatics have been described. Nanocarrier systems may induce cytotoxicity and/or genotoxicity, whereas their antige...

journal_title：Advanced drug delivery reviews

authors： Vega-Villa KR,Takemoto JK,Yáñez JA,Remsberg CM,Forrest ML,Davies NM

更新日期：2008-05-22 00:00:00

abstract：:In recent years, it has become increasingly evident that mammalian Toll-like receptors (TLRs) play a critical role in determining the outcome of virus infection. TLRs have evolved to recognize viral nucleic acids, and promote the stimulation of innate and adaptive immune responses. Interestingly, the study of mice har...

journal_title：Advanced drug delivery reviews

authors： Thompson JM,Iwasaki A

更新日期：2008-04-29 00:00:00

abstract：:The encapsulation of liquids and semi-solids provides solutions for convenient delivery through improved oral absorption of poorly water-soluble drugs. In addition, low dose (content uniformity), highly potent (containment), low melting point drugs, those with a critical stability profile and those for which a delayed...

journal_title：Advanced drug delivery reviews

authors： Cole ET,Cadé D,Benameur H

更新日期：2008-03-17 00:00:00

abstract：:Oral lipid-based drug delivery systems may include a broad range of oils, surfactants, and cosolvents. This diversity makes comparison of lipid-based formulations difficult. Although the relationship between formulation and drug absorption is understood at a conceptual level, performance in vivo cannot be predicted wi...

journal_title：Advanced drug delivery reviews

authors： Pouton CW,Porter CJ

更新日期：2008-03-17 00:00:00

abstract：:The percentage of new chemical entities synthesised with low aqueous solubility and high therapeutic efficacy is growing, this presents major challenges for the drug delivery scientists. The role of physicochemical properties in identification of suitable drug candidates for oral lipid-based delivery systems is discus...

journal_title：Advanced drug delivery reviews

authors： O'Driscoll CM,Griffin BT

更新日期：2008-03-17 00:00:00

abstract：:Cell-penetrating peptides (CPPs) traverse the membrane of biological cells at low micromolar concentrations and are able to take various cargo molecules along with. Despite large differences in their chemical structure, CPPs share the structural similarity of a high cationic charge density. This property confers to th...

journal_title：Advanced drug delivery reviews

authors： Ziegler A

更新日期：2008-03-01 00:00:00

abstract：:This review presents a summary of the various types of cellular therapy used to treat spinal cord injury. The inhibitory environment and loss of axonal connections after spinal cord injury pose many obstacles to regenerating the lost tissue. Cellular therapy provides a means of restoring the cells lost to the injury a...

journal_title：Advanced drug delivery reviews

authors： Willerth SM,Sakiyama-Elbert SE

更新日期：2008-01-14 00:00:00

abstract：:Progress in gene therapy has produced promising results that translate experimental research into clinical treatment. Gene modification has been extensively employed in cell transplantation. The main barrier is an effective gene delivery system. Several viral vectors were utilized in end-stage differentiated cells. Re...

journal_title：Advanced drug delivery reviews

authors： Lai Y,Drobinskaya I,Kolossov E,Chen C,Linn T

更新日期：2008-01-14 00:00:00

abstract：:PEGylation is a clinically proven strategy for increasing the therapeutic efficacy of protein-based medicines. Our approach to site-specific PEGylation exploits the thiol selective chemistry of the two cysteine sulfur atoms from an accessible disulfide. It involves two key steps: (1) disulfide reduction to release the...

journal_title：Advanced drug delivery reviews

authors： Brocchini S,Godwin A,Balan S,Choi JW,Zloh M,Shaunak S

更新日期：2008-01-03 00:00:00

abstract：:Functional nanofibrous scaffolds produced by electrospinning have great potential in many biomedical applications, such as tissue engineering, wound dressing, enzyme immobilization and drug (gene) delivery. For a specific successful application, the chemical, physical and biological properties of electrospun scaffolds...

journal_title：Advanced drug delivery reviews

authors： Liang D,Hsiao BS,Chu B

更新日期：2007-12-10 00:00:00

abstract：:Over recent years the research focus within the field of respiratory drug delivery has broadened to include a wide range of potential applications for inhalation by delivering drugs not just onto the lung mucosa but across it. The range of drugs being assessed is broad and includes both current and novel therapies and...

journal_title：Advanced drug delivery reviews

authors： Cryan SA,Sivadas N,Garcia-Contreras L

更新日期：2007-09-30 00:00:00

abstract：:The assessment of percutaneous permeation of molecules is one of the main steps in the initial design and later in the evaluation of dermal or transdermal drug delivery systems. The literature reports numerous ex vivo, in vitro and in vivo models used to determine drug skin permeation profiles and kinetic parameters, ...

journal_title：Advanced drug delivery reviews

authors： Godin B,Touitou E

更新日期：2007-09-30 00:00:00

abstract：:Cyclodextrins are useful functional excipients that have enjoyed widespread attention and use. The basis for this popularity from a pharmaceutical standpoint, is the ability of these materials to interact with poorly water-soluble drugs and drug candidates resulting in an increase in their apparent water solubility. T...

journal_title：Advanced drug delivery reviews

authors： Brewster ME,Loftsson T

更新日期：2007-07-30 00:00:00

abstract：:Regenerative medicine aims to create functional tissue replacements, typically through creating a controlled environment that promotes and directs the differentiation of stem or progenitor cells, either endogenous or transplanted. Scaffolds serve a central role in many strategies by providing the means to control the ...

journal_title：Advanced drug delivery reviews

authors： De Laporte L,Shea LD

更新日期：2007-05-30 00:00:00

abstract：:A wide range of polymeric scaffolds have been intensively studied for use as implantable and temporal devices in tissue engineering. Biodegradable and biocompatible scaffolds having a highly open porous structure and good mechanical strength are needed to provide an optimal microenvironment for cell proliferation, mig...

journal_title：Advanced drug delivery reviews

authors： Chung HJ,Park TG

更新日期：2007-05-30 00:00:00

abstract：:The cellular membrane constitutes an effective barrier that offers protection for the complex, yet highly ordered, intracellular environment that defines the cell. Passage of molecules across this barrier is highly regulated and highly restricted, with molecular size being the most significant criteria. Over the last ...

journal_title：Advanced drug delivery reviews

authors： Meade BR,Dowdy SF

更新日期：2007-03-30 00:00:00

abstract：:Synthetic polymers and nanomaterials display selective phenotypic effects in cells and in the body signal transduction mechanisms involved in inflammation, differentiation, proliferation, and apoptosis. When physically mixed or covalently conjugated with cytotoxic agents, bacterial DNA or antigens, polymers can drasti...

journal_title：Advanced drug delivery reviews

authors： Kabanov AV

更新日期：2006-12-30 00:00:00

abstract：:Synthetic polymer based Polyfectins (cationic polymer-DNA complex) have received intensive scientific research as they can potentially circumvent problems associated with viral vectors for gene therapy. These cationic macromolecules can readily condense DNA or RNA into stable nanostructures for use in gene delivery. R...

journal_title：Advanced drug delivery reviews

authors： Hunter AC

更新日期：2006-12-01 00:00:00

abstract：:The early impact of nanotechnology on medicine is beginning to get realized, with novel nanoscale therapeutic and diagnostic modalities under development or in clinical practice today. In this commentary the field of "nanomedicine" is briefly reviewed form the perspective of where we were; where we are today; and wher...

journal_title：Advanced drug delivery reviews

authors： Farokhzad OC,Langer R

更新日期：2006-12-01 00:00:00

abstract：:Quantitative structure-activity relationships have long been considered a vital component of drug discovery and development, providing insight into the role of molecular properties in the biological activity of similar and unrelated compounds. Recognition that in vitro bioassay and/or pre-clinical activity are insuffi...

journal_title：Advanced drug delivery reviews

authors： Mager DE

更新日期：2006-11-30 00:00:00

abstract：:Nucleic acids have gained a lot of interest for the treatment of ocular diseases. The first to enter in clinic has been Vitravene an antisense oligonucleotide for the treatment of cytomegalovirus (CMV) infection and more recently, research on aptamers have led to the marketing of anti-vascular endothelial growth facto...

journal_title：Advanced drug delivery reviews

authors： Fattal E,Bochot A

更新日期：2006-11-15 00:00:00

abstract：:Two-photon excitation imaging is the least invasive optical approach to study living tissues. We have established two-photon extracellular polar-tracer (TEP) imaging with which it is possible to visualize and quantify all exocytic events in the plane of focus within secretory tissues. This technology also enables esti...

journal_title：Advanced drug delivery reviews

authors： Kasai H,Kishimoto T,Nemoto T,Hatakeyama H,Liu TT,Takahashi N

更新日期：2006-09-15 00:00:00

abstract：:The recent introduction of multi-photon microscopy coupled with advances in optics, computer sciences and the available fluorophores used to label molecules of interest have empowered investigators to study the dynamic events within the functioning kidney at cellular and subcellular levels. This emerging technique, wi...

journal_title：Advanced drug delivery reviews

authors： Molitoris BA,Sandoval RM

更新日期：2006-09-15 00:00:00

abstract：:High affinity antibodies are crucial both for the discovery and validation of biomarkers for human health and disease and as clinical diagnostic and therapeutic reagents. This review describes some of the latest technologies for the design, mutation and selection of high affinity antibodies that provide a paradigm for...

journal_title：Advanced drug delivery reviews

authors： Wark KL,Hudson PJ

更新日期：2006-08-07 00:00:00

abstract：:Antibodies can have exquisite specificity of target recognition and thus generate highly selective outcomes following their systemic administration. While antibodies can have high specificity, the doses required to treat patients, particularly for a chronic condition, are typically large. Fortunately, advances in prod...

journal_title：Advanced drug delivery reviews

authors： Daugherty AL,Mrsny RJ

更新日期：2006-08-07 00:00:00

abstract：:Basic science advances in bone tissue engineering using osteoinductive protein therapy have already been translated to the use in patients with selected orthopedic problems. The story of the development of bone morphogenetic protein (BMP) osteoinductive therapy, from the discovery of this class of molecules in 1965 to...

journal_title：Advanced drug delivery reviews

authors： Nussenbaum B,Krebsbach PH

更新日期：2006-07-07 00:00:00

abstract：:Posterior segment drug delivery challenges inherent in the treatment of many sight-threatening diseases have become increasingly apparent. Therapeutic interventions for ocular diseases such as neovascular retinopathies, inflammatory and/or infectious diseases may involve drug delivery to vitreoretinal targets. An impo...

journal_title：Advanced drug delivery reviews

authors： Duvvuri S,Rittenhouse KD,Mitra AK

更新日期：2005-12-13 00:00:00

abstract：:To design an effective particulate drug delivery system having mucoadhesive function, several mucoadhesion tests for polymers and the resultant particulate systems were developed. Mucin particle method is a simple mucoadhesion test for polymers, in which the commercial mucin particles are used. By measuring the change...

journal_title：Advanced drug delivery reviews

authors： Takeuchi H,Thongborisute J,Matsui Y,Sugihara H,Yamamoto H,Kawashima Y

更新日期：2005-11-03 00:00:00

abstract：:The threat of bioterrorism worldwide has accelerated the demand for the development of therapies and vaccines against the Category B toxins: staphylococcal enterotoxin B (SEB), epsilon toxin (ETX) produced by Clostridium perfringens types B and D, and ricin, a natural product of the castor bean. The diverse and unique...

journal_title：Advanced drug delivery reviews

authors： Mantis NJ

更新日期：2005-06-17 00:00:00

abstract：:Mid-IR and Raman spectroscopy are versatile tools in pharmaceutics and biopharmaceutics, with a wide field of applications ranging from characterization of drug formulations to elucidation of kinetic processes in drug delivery. After an introduction to the basic principles of IR and Raman spectroscopy, new development...

journal_title：Advanced drug delivery reviews

authors： Wartewig S,Neubert RH

更新日期：2005-06-15 00:00:00

abstract：:Magnetic Marker Monitoring offers an alternative to investigate the behavior of solid dosage forms in the organs of the gastrointestinal tract without the need to apply radiation. For Magnetic Marker Monitoring, the dosage form is marked as a permanent magnetic dipole by the incorporation of small amounts of ferromagn...

journal_title：Advanced drug delivery reviews

authors： Weitschies W,Kosch O,Mönnikes H,Trahms L

更新日期：2005-06-15 00:00:00

abstract：:The three main organs affected by metastasis of all cancers include lungs, liver, and bone. Clinical confirmation of tumor spread to these organs is a negative prognostic sign that marks the stage when disease is rarely curable. Today, treatment of bone metastases is primarily palliative. The aims of treatment are to ...

journal_title：Advanced drug delivery reviews

authors： Bagi CM

更新日期：2005-05-25 00:00:00

abstract：:While a vast array of liposomes, peptides, and molecular conjugates have been evaluated for nonviral gene transfer, the entity containing the actual gene itself is almost always a plasmid. The layout of most plasmid DNA (pDNA) vectors is usually quite simple, consisting of a promoter, transgene, polyadenylation signal...

journal_title：Advanced drug delivery reviews

authors： Yew NS

更新日期：2005-04-05 00:00:00

abstract：:A mechanistic hypothesis is presented for how water-soluble guanidinium-rich transporters attached to small cargoes (MW ca. <3000) can migrate across the non-polar lipid membrane of a cell and enter the cytosol. Positively charged and water-soluble, arginine oligomers can associate with negatively charged, bidentate h...

journal_title：Advanced drug delivery reviews

authors： Rothbard JB,Jessop TC,Wender PA

更新日期：2005-02-28 00:00:00

abstract：:The effective delivery of antigens via the oral route is an extremely desirable goal. Mucosal delivery of antigens stimulates mucosal and systemic immunity without affecting maternal antibodies and reduces the need for sterile needles or trained personnel. To date, there are very few commercially available oral vaccin...

journal_title：Advanced drug delivery reviews

authors： Foster N,Hirst BH

更新日期：2005-01-10 00:00:00